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A back-end framework primarily simplifies server-side application development. This involves managing the logic behind what the application does, processing requests from clients, interacting with a database, and handling things like authentication and authorization. The framework provides tools, libraries, and conventions that streamline these processes, allowing developers to write less code and focus more on building features that meet user needs.

In this context, while user interface design pertains to the visual aspects and how users interact with a website or application, that falls under front-end development. Database management does involve back-end skills, but it is often a specific aspect that may be handled by database management systems rather than solely the framework itself. Client-side scripting refers to code that runs in the user's browser and is generally handled by front-end technologies, which are separate from the duties of a back-end framework. Thus, the focus of a back-end framework is specifically geared towards simplifying and enhancing server-side application development.